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ATM anticorps

ATM Reactivité: Humain WB Hôte: Souris Monoclonal 4H1 unconjugated
N° du produit ABIN1449283
  • Antigène Voir toutes ATM Anticorps
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Reactivité
    • 163
    • 84
    • 34
    • 4
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 139
    • 24
    • 6
    • 2
    Souris
    Clonalité
    • 133
    • 38
    Monoclonal
    Conjugué
    • 82
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Cet anticorp ATM est non-conjugé
    Application
    • 74
    • 50
    • 39
    • 37
    • 28
    • 26
    • 22
    • 22
    • 19
    • 13
    • 8
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    CP-CFIKKPFDRG EVESMEDDTN GN
    Specificité
    This antibody reacts with ATM.
    Réactivité croisée (Details)
    Species reactivity (tested):Human
    Immunogène
    Carrier protein (CP) conjugated synthetic peptide
    Clone
    4H1
    Isotype
    IgG1
    Top Product
    Discover our top product ATM Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Protein A agarose, PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
    Agent conservateur
    Without preservative
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Upon receipt, store (in aliqouts) at -20 °C.
  • Antigène
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Autre désignation
    ATM (ATM Produits)
    Synonymes
    anticorps ATM, anticorps Atm, anticorps CG6535, anticorps Dmel\\CG6535, anticorps Tefu, anticorps atm, anticorps atm/tefu, anticorps dATM, anticorps tef, anticorps Xatm, anticorps at1, anticorps atdc, anticorps tel1, anticorps telo1, anticorps AT1, anticorps ATA, anticorps ATC, anticorps ATD, anticorps ATDC, anticorps ATE, anticorps TEL1, anticorps TELO1, anticorps AI256621, anticorps C030026E19Rik, anticorps telomere fusion, anticorps ATM serine/threonine kinase L homeolog, anticorps ATM serine/threonine kinase, anticorps ataxia telangiectasia mutated, anticorps ataxia telangiectasia mutated (atm), anticorps serine/threonine-protein kinase ATM, anticorps tefu, anticorps atm.L, anticorps atm, anticorps ATM, anticorps EDI_100660, anticorps CpipJ_CPIJ001772, anticorps BDBG_08252, anticorps PAAG_02532, anticorps MCYG_05088, anticorps VDBG_06833, anticorps ACLA_015700, anticorps LOC5565620, anticorps MGYG_07634, anticorps PGTG_14279, anticorps Atm
    Sujet
    ATM (ataxia telangiectasia mutated) encodes a 350-370 kDa protein. The ATM protein belongs to a family of protein kinases that appear to be involved in cell cycle control and DNA damage response. ATM kinase activity is enhanced immediately after exposure of cells to DNA double strand breaks. The C-terminal region of the protein has extensive homology to the catalytic domain of PI-3 (phosphatydilinositol-3) kinase, FAT (FRAP/ATM/TRAPP), and FAT-C (FAT-carboxy-terminal). ATM activates p53, increasing p21Cip1 levels, thus blocking activation of cdk2. That results in blockage of the G1/S transition.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1
    ID gène
    472
    NCBI Accession
    NP_000042
    UniProt
    Q13315
    Pathways
    Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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