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GFRA1 anticorps (Extracellular Domain)

GFRA1 Reactivité: Humain WB Hôte: Souris Monoclonal 4G10 unconjugated
N° du produit ABIN1449285
  • Antigène Voir toutes GFRA1 Anticorps
    GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
    Épitope
    • 16
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-440, Extracellular Domain
    Reactivité
    • 55
    • 37
    • 19
    • 16
    Humain
    Hôte
    • 50
    • 5
    • 2
    Souris
    Clonalité
    • 52
    • 5
    Monoclonal
    Conjugué
    • 28
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GFRA1 est non-conjugé
    Application
    • 42
    • 16
    • 15
    • 13
    • 13
    • 13
    • 10
    • 9
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    This antibody detects GFRα1 (60 kDa). Reacts with HCC-1500, MCF-7, but NOT with BT-20, ZR-75-1.
    Réactivité croisée (Details)
    Species reactivity (tested):Human
    Purification
    Protein A agarose
    Immunogène
    Tecombinant human GFRalpha1 extracellular domain (24-440 aa)
    Clone
    4G10
    Isotype
    IgG2b
    Top Product
    Discover our top product GFRA1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    Agent conservateur
    Without preservative
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Upon receipt, store (in aliqouts) at -20 °C.
  • Antigène
    GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
    Autre désignation
    GFRA1 / GDNFR-alpha (GFRA1 Produits)
    Synonymes
    anticorps gdnfr, anticorps ret1l, anticorps retl1, anticorps trnr1, anticorps gdnfra, anticorps MGC122616, anticorps gfr-alpha-1, anticorps GDNFR, anticorps GDNFRA, anticorps GFR-ALPHA-1, anticorps RET1L, anticorps RETL1, anticorps TRNR1, anticorps GDNFRALPHA, anticorps GFRA1, anticorps AU042498, anticorps gfralpha1a, anticorps zgc:110129, anticorps GDNF family receptor alpha 1, anticorps glial cell line derived neurotrophic factor family receptor alpha 1, anticorps gdnf family receptor alpha 1a, anticorps gfra1, anticorps GFRA1, anticorps Gfra1, anticorps gfra1a
    Sujet
    Glial cell line-derived neurotrophic factor (GDNF) family plays a critical role in neurodevelopment and survival of central and peripheral neurons. The biological activity of GDNF family through receptor protein tyrosine kinase Ret and require a ligand specific co-receptor a (GFRa1, binds GDNF, whereas GFRa2 binds NRTN, GFRa3 binds ARTN and GFRa4 binds PSPN). Human GFRa1 is constituted from 465 amino acids and attach to the cell membrane by glycosylphosphatidylinositol (GPI) anchoring manner. It is widely accepted that homodimeric GDNF induce the complex formation of GFRa1 and further the stoichiometry of the signaling complex with GDNF2-GFRa12-Ret2, but the mechanism of complex formation remain unclear.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1
    ID gène
    2674
    NCBI Accession
    NP_001138925
    UniProt
    P56159
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