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CD5 anticorps (APC)

CD5 Reactivité: Humain FACS Hôte: Souris Monoclonal L17F12 APC
N° du produit ABIN1449304
  • Antigène Voir toutes CD5 Anticorps
    CD5
    Reactivité
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    • 96
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    • 16
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    • 5
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    Humain
    Hôte
    • 174
    • 81
    • 62
    • 1
    Souris
    Clonalité
    • 246
    • 70
    Monoclonal
    Conjugué
    • 114
    • 39
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    Cet anticorp CD5 est conjugé à/à la APC
    Application
    • 244
    • 109
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    Flow Cytometry (FACS)
    Réactivité croisée (Details)
    Species reactivity (tested):Human
    Immunogène
    Human acute lymphoblastic leukemia (ALL) T cells
    Clone
    L17F12
    Isotype
    IgG2a
    Top Product
    Discover our top product CD5 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS, 15 mM sodium azide, 0.2 % (w/v) high-grade protease free Bovine Serum Albumin
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    DO NOT FREEZE! This products is photosensitive and should be protected from light.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 2-8 °C.
  • Antigène
    CD5
    Autre désignation
    CD5 (CD5 Produits)
    Synonymes
    anticorps CD5, anticorps Ly-1, anticorps Ly-12, anticorps Ly-A, anticorps Lyt-1, anticorps LEU1, anticorps T1, anticorps CD5 molecule, anticorps CD5 antigen, anticorps CD5 molecule like, anticorps Cd5 molecule, anticorps CD5, anticorps Cd5, anticorps CD5L
    Sujet
    CD5 antigen (T1, 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
    ID gène
    921
    NCBI Accession
    NP_055022
    UniProt
    P06127
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