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Détail du produit
anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) anticorps
Aperçu
| Antigène: | Nuclease-sensitive element-binding protein 1 (YBX1) |
| Clonalité: | Polyclonal |
| Application: | Western Blotting (WB), Immunohistochemistry (IHC) |
| Reactivité: | Human |
| Hôte: | Rabbit |
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3 références disponible |
| Quantité: | |
| Prix: | 301,50 $ (Plus frais de livraison $25 et TVA, Invoice in EUR) |
| Numéro du produit: | ABIN155053 |
| Disponibilité: | Envoi sous 1 jour ouvrable |
Description du produit » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) anticorps
| Antigène | Nuclease-sensitive element-binding protein 1 (YBX1) |
| ID gène | 4904 |
| Reactivité | Human |
| Clonalité | Polyclonal |
| Format | Affinity purified |
| Isotype | IgG »Anticorps secondaires correspondants |
| Description | Members of Y-box binding protein family all contain a DNA binding domain, called the cold shock domain, comprising of 80 amino acids, which is highly conserved from prokaryotes to eukaryotes. Y-box binding protein-1 (YB-1) is a prototypic member of this family and was originally isolated as a DNA binding protein recognizing the Y-box sequence within the MHC class II gene promoter region. This box is found in the promoter region of several genes involved in positive regulation of cell cycle, such as proliferating cell nuclear antigen, DNA topoisomerase IIa, DNA-polymerase-alpha and cyclins. Consequently, YB-1 is thought to play crucial roles for cell proliferation and carcinogenesis. YB-1 has been reported to be a prognostic marker of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and synovial sarcoma. These findings indicate the significance of YB-1 for the progression of malignant diseases. Alternative names: BP-8, CSDA2, CSDB, DBPB, MDR-NF1, MGC104858, MGC110976, MGC117250, NSEP-1, NSEP1, YB-1, YB1, YBX1, DNA-binding protein B, Y box-binding protein I, nuclease sensitive element binding protein 1. |
| Hôte | Rabbit |
Applications » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) anticorps
| Application | Western Blotting (WB), Immunohistochemistry (IHC) |
| Indications d'application | WB: 1:1000. IHC (p): 1:50 to 1:200 depending on type of tissue |
| Concentration | 200ug/ml |
| Stock | Store aliquots at -20 C. Avoid repeated thawing and freezing |
| Domaine de recherche | Cancer |
| Restrictions | For Research Use only |
Références » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) anticorps
| Références |
Krohn R, Raffetseder U, Bot I et al.: "Y-Box Binding Protein-1 Controls CC Chemokine Ligand-5 (CCL5) Expression in Smooth Muscle Cells and Contributes to Neointima Formation in Atherosclerosis-Prone Mice" In: Circulation
, Vol. Epub ahead of print, 2007 (PubMed)
Frye, Halfter, Djudjaj et al.: "Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen." In: EMBO reports , Vol. 10, Issue 7, pp. 783-9, 2009 (PubMed) Rauen, Raffetseder, Frye et al.: "YB-1 acts as ligand for Notch-3 receptors and modulates receptor activation." In: The Journal of biological chemistry , 2009 (PubMed) |
Images » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) anticorps
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