Chromosome 1 Open Reading Frame 85 (C1ORF85) anticorps (HRP)

Détails pour le produit réf. ABIN1712013, Fournisseur: Connectez-vous pour afficher
Antigène
  • NCU-G1
  • C1orf85
  • 0610031j06rik
  • AB027141
  • CA085 protein
  • chromosome 1 open reading frame 85
  • chromosome 3 open reading frame, human C1orf85
  • kidney predominant protein NCU-G1
  • RIKEN cDNA 0610031J06 gene
  • ca085
  • C1orf85
  • C3H1orf85
  • RGD1303130
  • 0610031J06Rik
Reactivité
Humain, Souris, Rat (Rattus)
16
15
14
Hôte
Lapin
17
Clonalité
Polyclonal
Conjugué
HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
13
4
3
2
1
1
Options
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Supplier Product No.
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Immunogène KLH conjugated synthetic peptide derived from human C1orf85
Isotype IgG
Purification Purified by Protein A.
Autre désignation C1orf85
Sujet

C1orf85, also known as Lysosomal protein NCU-G1, is a 406 amino acid single-pass membrane protein that is highly glycosylated on its amino-terminal end. Transcription of the gene encoding C1orf85 is activated by TFEB, a transcription factor that specifically recognizes and binds E-box sequences. There are two isoforms of C1orf85 that are produced as a result of alternative splicing events. The C1orf85 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Synonyms: C1orf85, Chromosome 1 open reading frame 85, Lysosomal protein NCU-G1, NCUG1_HUMAN, PSEC0030, UNQ2553/PRO6182.

ID gène 112770
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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