Destrin anticorps (Destrin (Actin Depolymerizing Factor)) (HRP)

Details for Product anti-DSTN Antibody No. ABIN1712033, Fournisseur: Connectez-vous pour afficher
Antigène
  • Dstn
  • DSTN
  • adf
  • actdp
  • ba462d18.2
  • LOC100190417
  • 2610043P17Rik
  • ADF
  • AU042046
  • Dsn
  • corn1
  • sid23p
  • ACTDP
  • bA462D18.2
  • destrin
  • destrin-like 1
  • destrin (actin depolymerizing factor)
  • destrin
  • destrin-like
  • Dstnl1
  • DSTN
  • dstn
  • LOC100190417
  • LOC100341305
  • LOC100358081
  • Dstn
Reactivité
Humain, Souris, Rat (Rattus)
77
26
25
13
11
2
2
2
2
1
1
1
1
1
1
Hôte
Lapin
50
27
Clonalité
Polyclonal
Conjugué
Cet anticorp Destrin est conjugé à/à la HRP
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
41
33
23
15
13
12
2
1
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human Destrin
Isotype IgG
Purification Purified by Protein A.
Autre désignation Destrin (DSTN Antibody Extrait)
Sujet

Actin-depolymerizing factor (ADF), also known as destrin, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. The Actin-depolymerizing activity of ADF is reversibly controlled by changes in KCl concentration but is insensitive to calcium concentration. ADF depolymerizes F-Actin by interacting directly with F-Actin protomers. ADF shares 71 % sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. The difference in the function of ADF and Cofilin results from the subtle difference in their amino acid sequence rather than possible differences in posttranslational modifications. As a result of different cleavage sites on ADF and Cofilin, the proteins differ in their overall tertiary folds. Sensitivity to polyphosphoinositides may be a common feature in vitro among Actin-binding proteins such as ADF and Cofilin that can bind to G-Actin and regulate the state of Actin polymerization. ADF and Cofilin are Actin-depolymerizing proteins whose activities are possibly regulated by their phosphorylation/dephosphorylation.

Synonyms: 2610043P17Rik, ACTDP, Actin depolymerizing factor, Actin-depolymerizing factor, ADF, AU042046, bA462D18.2, corn1, DEST_HUMAN, Destrin actin depolymerizing factor, Destrin, DSN, Dstn, Sid 23, sid23p.

ID gène 11034
Domaine de recherche Signaling, Cytoskeleton, Microfilaments
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months