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FRAT2 anticorps (AA 131-230) (HRP)

FRAT2 Reactivité: Souris WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal HRP
N° du produit ABIN1712054
  • Antigène Voir toutes FRAT2 Anticorps
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    Épitope
    • 14
    • 9
    • 8
    • 7
    • 1
    AA 131-230
    Reactivité
    • 17
    • 14
    Souris
    Hôte
    • 29
    • 1
    • 1
    Lapin
    Clonalité
    • 31
    Polyclonal
    Conjugué
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FRAT2 est conjugé à/à la HRP
    Application
    • 30
    • 15
    • 14
    • 13
    • 13
    • 13
    • 7
    • 5
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Cow,Sheep
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human FRAT2
    Isotype
    IgG
    Top Product
    Discover our top product FRAT2 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    Autre désignation
    FRAT2 (FRAT2 Produits)
    Synonymes
    anticorps FRAT2, anticorps FRAT2, WNT signaling pathway regulator, anticorps frequently rearranged in advanced T cell lymphomas 2, anticorps frequently rearranged in advanced T-cell lymphomas 2, anticorps FRAT2, anticorps Frat2
    Sujet

    Synonyms: Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2, FRAT2_HUMAN.

    Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

    ID gène
    23401
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