G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors and heptahelical receptors, are a protein family which interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers such as diacylglycerol, cyclic AMP, inositol phosphates, and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. G protein receptor 84 (GPR84), a member of the GCPR 1 family, is an orphan GCPR expressed in bone marrow, brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta, intestine, lung and peripheral blood leukocytes. In activated T cells, GPR84 regulates early interleukin-4 (IL-4) gene expression.
Subcellular location: Extracellular
Synonyms: GPCR EX33, EX 33, EX33, G protein coupled receptor 84, G protein coupled receptor EX 33, G protein coupled receptor EX33, G-protein coupled receptor 84, GPCR 4, GPCR4, GPR 84, GPR84, GPR84_HUMAN, Inflammation related G protein coupled receptor EX 33, Inflammation related G protein coupled receptor EX33, Inflammation-related G-protein coupled receptor EX33, GPCR GPR84.