PSMD10 is a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
Synonyms: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit p28, Ankyrin repeat protein, dJ889N15.2, Gankyrin, Hepatocellular carcinoma-associated protein p28 II, p28, p28GANK, Proteasome prosome, macropain 26S subunit, non ATPase, 10, PSD10_HUMAN, Psmd10.