SIX Homeobox 2 (SIX2) anticorps (HRP)

Détails pour le produit réf. ABIN1712087, Fournisseur: Connectez-vous pour afficher
Antigène
  • six1b
  • six2
  • zgc:92332
  • six2-A
  • sine oculis homeobox homolog 1a
  • sine oculis-related homeobox 2
  • SIX homeobox 2
  • six1a
  • Six2
  • six2
  • SIX2
Alternatives
anti-Humain SIX Homeobox 2 anticorps pour Immunofluorescence (fixed cells)
Reactivité
Humain, Souris, Rat (Rattus)
51
22
21
2
2
2
2
2
2
2
1
1
1
1
Hôte
Lapin
44
7
Clonalité
Polyclonal
Conjugué
HRP
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
36
25
13
7
6
3
2
2
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human SIX2
Isotype IgG
Purification Purified by Protein A.
Autre désignation Six2 (SIX2 Antibody Extrait)
Sujet

The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Six4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint. Six2 is highly expressed in fetal tissues but expression is limited in adult tissues.

Synonyms: Homeobox protein SIX2, OTTHUMP00000201649, Sine oculis homeobox Drosophila homolog 2, Sine oculis homeobox homolog 2, Sine oculis homeobox homolog 2 Drosophila, SIX homeobox 2, Six2, SIX2_HUMAN.

ID gène 10736
Domaine de recherche Organogenesis, Transcription Factors
Pathways Protein targeting to Nucleus
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months