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The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
Synonyms: Ezrin phospho Y146, Ezrin phospho Tyr146, p-Ezrin phospho Y146, CVIL, CVL, cytovillin 2 , Cytovillin , DKFZp762H157, FLJ26216, MGC1584, p81, VIL 2 , VIL2, Villin 2, Villin2, EZRI_HUMAN.