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Stratifin anticorps (SFN) (HRP)

Détail du produit anti-SFN anticorps No. ABIN1712101, Fournisseur: Connectez-vous pour afficher
Antigène
  • YWHAS
  • Er
  • Mme1
  • Ywhas
  • stratifin
  • SFN
  • Sfn
Alternatives
anti-Humain Stratifin anticorps pour Immunohistochemistry (Paraffin-embedded Sections)
Reactivité
Humain, Souris, Rat (Rattus)
193
67
52
15
14
14
11
10
8
7
5
4
4
2
2
2
1
1
1
1
1
Hôte
Lapin
141
37
21
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp Stratifin est conjugé à/à la HRP
12
9
7
6
6
6
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
172
81
71
48
43
22
21
18
13
4
3
3
2
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human 14-3-3 sigma
Isotype IgG
Purification Purified by Protein A.
Autre désignation 14-3-3 sigma (SFN Antibody Extrait)
Sujet

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.


Synonyms: 14 3 3 protein sigma, 14-3-3 protein sigma, 1433S_HUMAN, Epithelial cell marker protein 1, Er, HME 1, HME1, MGC143283, Mkrn3, Mme1, OTTHUMP00000004242, RP23 137L22.11, SFN, SFN protein, Stratin, YWHAS.
ID gène 2810
Pathways Signalisation p53, Myometrial Relaxation and Contraction
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months