NAE1 anticorps (AA 401-500) (HRP)

N° du produit ABIN1712107

Détail du produit anti-NAE1 anticorps (HRP)

Antigène: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Épitope: AA 401-500

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAE1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human APPBP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NAE1

Antigène: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Autre désignation: APPBP1 (NAE1 Produits)

Synonymes: anticorps APPBP1, anticorps CG7828, anticorps Dmel\\CG7828, anticorps anon-WO0140519.225, anticorps dAPP-BP1, anticorps dAPPBP1, anticorps A-116A10.1, anticorps ula-1, anticorps Appbp1, anticorps 59kDa, anticorps appbp1, anticorps zgc:66148, anticorps beta-Amyloid precursor protein binding protein 1, anticorps NEDD8 activating enzyme E1 subunit 1, anticorps NEDD8 activating enzyme E1 subunit 1 S homeolog, anticorps nedd8 activating enzyme E1 subunit 1, anticorps NEDD8-activating enzyme E1 regulatory subunit, anticorps APP-BP1, anticorps NAE1, anticorps Nae1, anticorps nae1.S, anticorps nae1, anticorps ula-1

Sujet:

Synonyms: HPP1, ula-1, APPBP1, A-116A10.1, NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1

Background: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

ID gène: 8883

UniProt: Q13564