FYTTD1 is a 318 amino acid protein belonging to the UIF family. FYTTD1 localizes to nucleus and is required for mRNA export from nucleus to cytoplasm. Functioning as an adaptor, FYTTD1 utilizes the BAT1/DDX39-TAP pathway, which is essential for efficient mRNA export and nuclear pore delivery. FYTTD1 interacts with SSRP1, a protein that is necessary for its recruitment of mRNAs, in addition to a mutually exclusive interaction with BAT1/DDX39 and TAP. FYTTD1 exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 3q29.
Synonyms: DKFZp761B1514, Forty two three domain containing 1, Forty two three domain containing protein 1, Forty-two-three domain-containing protein 1, FYTTD 1, fyttd1, OTTHUMP00000208028, OTTHUMP00000208031, OTTHUMP00000208032, Protein 40 2 3, Protein 40-2-3, UAP56 interacting factor, UAP56-interacting factor, U, U_HUMAN.