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RANK anticorps (CD265) (HRP)

Détail du produit anti-CD265 anticorps No. ABIN1712150, Fournisseur: Connectez-vous pour afficher
Antigène
  • Ly109
  • ODFR
  • OFE
  • Rank
  • TRANCE-R
  • mRANK
  • CD265
  • FEO
  • LOH18CR1
  • OPTB7
  • OSTS
  • PDB2
  • RANK
  • TRANCER
  • RGD1563614
  • tumor necrosis factor receptor superfamily, member 11a
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator
  • Tnfrsf11a
  • TNFRSF11A
Alternatives
anti-Humain RANK anticorps pour Flow Cytometry
Reactivité
Humain, Souris, Rat (Rattus)
69
37
16
Hôte
Lapin
59
15
9
1
Clonalité
Polyclonal
Conjugué
Cet anticorp RANK est conjugé à/à la HRP
7
6
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
56
27
24
19
14
13
12
2
1
Options
Fournisseur
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Immunogène KLH conjugated synthetic peptide derived from human RANK
Isotype IgG
Purification Purified by Protein A.
Autre désignation Rank (CD265 Antibody Extrait)
Sujet

CD265 is a member of the tumor necrosis factor receptor (TNFR) family. Human and murine CD265 share 81 % amino acid identity in their extracellular domains. CD265 is widely expressed, with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. CD265 is also expressed in dendritic cells. RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of CD265. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for CD265. The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. The soluble form of CD265 is able to block TRANCE induced biological activity. The binding of anti-CD265 to cell surface CD265 triggers signal transduction and induces CD265 mediated bioactivity.

Subcellular location: Extracellular


Synonyms: TNFRSF11A, CD 265, CD265, CD265 antigen, Activator of NFKB, EOF, FEO, mRANK, NFKB activator, ODFR, OFE, Osteoclast dferentiation factor receptor, PDB 2, Receptor activator of NF KB, receptor activator of nuclear factor kappa B, TNFRSF 11A, TNFSF11, TRANCE R, RANK receptor, TNR11_HUMAN.
Domaine de recherche Cardiovascular, Atherosclerosis, Extracellular Matrix, Innate Immunity, Cytokines
Pathways Signalisation NF-kappaB
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months