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Apolipoproteins are protein components of plasma lipoproteins. ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins. ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel â^ barrel which binds retinol and retinoic acid. ApoM may play a key role in reverse cholesterol transport. It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). ApoM is important for the preâ^-HDL formation. Preâ^-HDL is an important acceptor of peripheral cellular cholesterol. The concentration of ApoM in plasma strongly correlates with total cholesterol. Low concentrations of ApoM in plasma is associated with diabetes.
Synonyms: Apo M, Apo-M, Apolipoprotein M, ApoM, APOM_HUMAN, G3A, HSPC336, MGC22400, NG20, NG20 like protein, Protein G3a.