Protein Aurora Borealis anticorps (HRP)

Détails pour le produit réf. ABIN1712184, Fournisseur: Connectez-vous pour afficher
Antigène
  • CG6897
  • Dmel\\CG6897
  • zgc:101616
  • C13orf34
  • 6720463M24Rik
  • AI317232
  • RGD1309522
  • c13orf34
  • C12H13orf34
  • aurora borealis
  • bora, aurora kinase A activator
  • protein aurora borealis
  • bora
  • Tsp_06066
  • Bora
  • BORA
Reactivité
Humain, Souris, Rat (Rattus)
39
30
30
Hôte
Lapin
37
2
Clonalité
Polyclonal
Conjugué
HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
24
17
17
13
11
7
4
3
1
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Immunogène KLH conjugated synthetic peptide derived from human BORA
Isotype IgG
Purification Purified by Protein A.
Autre désignation Bora
Sujet

Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.

Synonyms: Aurora borealis, bora, BORA_HUMAN, C13orf34, Chromosome 13 open reading frame 34, FLJ22624, HsBora, Protein aurora borealis, RP11-342J4.2.

ID gène 79866
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months