Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 (SLC1A6) anticorps (HRP)

Détails pour le produit réf. ABIN1712249, Fournisseur: Connectez-vous pour afficher
Antigène
  • SLC1A6
  • zgc:171923
  • EAAT4
  • solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
  • SLC1A6
  • slc1a6
  • LOC100224299
  • Slc1a6
Alternatives
anti-Humain Solute Carrier Family 1 (High Affinity Aspartate/glutamate Transporter), Member 6 anticorps pour Western Blotting
Reactivité
Humain, Souris, Rat (Rattus)
41
31
27
3
2
2
2
2
1
1
1
1
1
Hôte
Lapin
40
5
Clonalité
Polyclonal
Conjugué
HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
28
14
13
7
3
2
2
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human EAAT4
Isotype IgG
Purification Purified by Protein A.
Autre désignation Eaat4 (SLC1A6 Antibody Extrait)
Sujet

Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering.

Subcellular location: Extracellular

Synonyms: Excitatory amino acid transporter 4, High affinity neuronal glutamate transporter, MGC33092, MGC43671, Sodium dependent glutamate/aspartate transporter, Solute carrier family 1 high affinity aspartate/glutamate transporter member 6, Solute carrier family 1 member 6,

ID gène 6511
Domaine de recherche Neurology, Amino Acids
Pathways Dicarboxylic Acid Transport
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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