Exosome Component 10 (EXOSC10) anticorps (HRP)

Détails pour le produit réf. ABIN1712261, Fournisseur: Connectez-vous pour afficher
Antigène
  • Pmscl2
  • zgc:55695
  • pm-scl
  • pm/scl-100
  • pmscl
  • pmscl2
  • rrp6
  • rrp6p
  • EXOSC10
  • 201.t00018
  • 21.m02990
  • DDBDRAFT_0203581
  • DDBDRAFT_0233752
  • DDB_0203581
  • DDB_0233752
  • PM-Scl
  • PM/Scl-100
  • PMSCL
  • PMSCL2
  • RRP6
  • Rrp6p
  • p2
  • p3
  • p4
  • exosome component 10
  • 3'-5' exonuclease
  • Exosome component 10
  • exosc10
  • EXOSC10
  • EHI_021400
  • BBOV_IV002650
  • CpipJ_CPIJ003896
  • CMU_031760
  • Tsp_05247
  • exosx
  • Exosc10
Reactivité
Humain, Souris, Rat (Rattus)
42
26
24
6
6
5
3
2
1
1
Hôte
Lapin
39
3
Clonalité
Polyclonal
Conjugué
HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
26
13
13
9
8
3
3
3
Options
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
Connectez-vous pour afficher
Request

Ce produit gratuit

Envoyez-nous votre proposition de validation. J'aimerais valider ce produit

Savoir plus

Immunogène KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2
Isotype IgG
Purification Purified by Protein A.
Autre désignation Exosc10/Pmscl2 (EXOSC10 Antibody Extrait)
Sujet

The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3’ region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3’-5’ enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.

Synonyms: Autoantigen PM/Scl 2, Exosc10, Exosome component 10, EXOSX_HUMAN, P100 polymyositis scleroderma overlap syndrome associated autoantigen, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, p2, p3, p4, PM Scl, PM/Scl 100, PM/Scl-100, PMSCL, PMSCL2, Polymyositis/scleroderma autoantigen 100 kDa, Polymyositis/scleroderma autoantigen 2 100 kDa, Polymyositis/scleroderma autoantigen 2, RRP6, Rrp6p.

ID gène 5394
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months