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Fukutin anticorps (FKTN) (HRP)

Détail du produit anti-FKTN anticorps No. ABIN1712291, Fournisseur: Connectez-vous pour afficher
Antigène
  • FCMD
  • fcmd
  • im:7163166
  • zgc:162828
  • FKTN
  • CMD1X
  • LGMD2M
  • MDDGA4
  • MDDGB4
  • MDDGC4
  • D830030O17Rik
  • Fcmd
  • Fukuyama type congenital muscular dystrophy (fukutin)
  • fukutin
  • Fukutin
  • fukutin-like
  • FCMD
  • FKTN
  • fktn
  • Bm1_09375
  • Bm1_09380
  • Bm1_44655
  • Fktn
  • LOC536891
Alternatives
anti-Humain Fukutin anticorps pour ELISA
Reactivité
Humain, Souris, Rat (Rattus)
55
40
26
7
7
5
5
5
4
4
3
2
2
1
Hôte
Lapin
63
1
Clonalité
Polyclonal
Conjugué
Cet anticorp Fukutin est conjugé à/à la HRP
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
47
29
21
14
13
9
6
1
1
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human Fukutin
Isotype IgG
Purification Purified by Protein A.
Autre désignation Fukutin (FKTN Antibody Extrait)
Sujet

Fukutin, a secreted protein, is expressed in various tissues in normal individuals. Fukutin colocalizes with a Golgi marker and a granular cytoplasmic distribution, suggesting that fukutin passes through the Golgi before being packaged into secretory vesicles. Fukutin may be located in the extracellular matrix, where it interacts with and reinforces a large complex encompassing the outside and inside of muscle membranes, alternatively, as a secreted protein, fukutin may cause muscular dystrophy by an unknown mechanism. The fukutin gene is expressed at similar levels in control fetal and adult brain, but is much reduced in Fukuyama congenital muscular dystrophy (FCMD) brains. Fukutin deficiency affects the modification of glycosylation of DAG1 (i±-dystroglycan), which then cannot localize or function properly and may be degraded or eluted from the extracellular surface membrane of the muscle fiber. FCMD is the first human disease known to be caused by an ancient retrotransposal integration. The gene which encodes fukutin maps to human chromosome 9q31.


Synonyms: C10orf125, Chromosome 10 open reading frame 125, FUCM_HUMAN, Fucose mutarotase, FUCU, Protein fucU homolog.
ID gène 282969
Pathways Regulation of Carbohydrate Metabolic Process
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months