FUSIP1 is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2â^ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing.
Synonyms: 40 kDa SR repressor protein, 40 kDa SR-repressor protein, Anti TLS associated protein with SR repeats, arginine/serine-rich 13A, FUS interacting protein serine arginine rich 1, FUS interacting protein serine arginine rich 2, FUS interacting serine arginine rich protein 1, FUS-interacting serine-arginine-rich protein 1, FUSIP1, FUSIP2, NSSR, OTTHUMP00000015774, Serine arginine repressor protein 40 kDa, Serine/arginine-rich splicing factor 10, SFRS13, SFRS13A, Splicing factor, Splicing factor arginine serine rich 13, Splicing factor SRp38, SRp38, SRp40, SRrp40, SRS10_HUMAN, Srsf10, TASR, TASR1, TASR2, TLS associated protein TASR1, TLS associated protein TASR2, TLS associated protein with Ser Arg repeats, TLS associated protein with SR repeats, TLS associated serine arginine protein 1, TLS associated serine arginine protein 2, TLS associated serine arginine protein, TLS associated SR protein, TLS-associated protein with Ser-Arg repeats, TLS-associated protein with SR repeats, TLS-associated serine-arginine protein, TLS-associated SR protein.