Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) anticorps (HRP)

Détails pour le produit réf. ABIN1712296, Fournisseur: Connectez-vous pour afficher
Antigène
  • zgc:110190
  • zgc:92742
  • NR1H4
  • BAR
  • FXR
  • HRR-1
  • HRR1
  • RIP14
  • AI957360
  • Fxr
  • Rxrip14
  • nuclear receptor subfamily 1, group H, member 4
  • nr1h4
  • NR1H4
  • LOC100219563
  • Nr1h4
Alternatives
anti-Humain Nuclear Receptor Subfamily 1, Group H, Member 4 anticorps pour ELISA
Reactivité
Humain
132
28
27
8
6
5
5
4
4
4
1
1
Hôte
Lapin
101
18
15
Clonalité
Polyclonal
Conjugué
HRP
12
10
8
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
98
60
19
19
13
9
4
4
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human Bile Acid Receptor NR1H4
Isotype IgG
Purification Purified by Protein A.
Autre désignation Fxr/Bile Acid Receptor Nr1h4 (NR1H4 Antibody Extrait)
Sujet

The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed â€orphan receptors†because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

Subcellular location: Nucleus

Synonyms: BAR, FXR, HRR1, HRR-1, PFIC5, RIP14, Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4

ID gène 9971
UniProt Q96RI1
Domaine de recherche Signaling, Metabolism
Pathways Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months