GEM anticorps (GTP Binding Protein Overexpressed in Skeletal Muscle) (HRP)

Details for Product anti-GEM Antibody No. ABIN1712312, Fournisseur: Connectez-vous pour afficher
Antigène
  • gem
  • rad
  • rad1
  • rem3
  • zgc:153003
  • GEM
  • kir
  • xgem
  • DKFZp470D0612
  • LOC100221129
  • AV020497
  • KIR
  • Ras-related associated with diabetes
  • GTP binding protein overexpressed in skeletal muscle
  • GTP binding protein (gene overexpressed in skeletal muscle)
  • rrad
  • gem
  • GEM
  • LOC100221129
  • Gem
Reactivité
Humain, Souris, Rat (Rattus)
58
29
27
6
4
4
4
4
3
2
2
1
1
Hôte
Lapin
38
15
5
Clonalité
Polyclonal
Conjugué
Cet anticorp GEM est conjugé à/à la HRP
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
44
22
13
12
10
1
1
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human GEM
Isotype IgG
Purification Purified by Protein A.
Autre désignation Gem (GEM Antibody Extrait)
Sujet

Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which lack typical C-terminal amino acid motifs for isoprenylation. Rad and Gem bind calmodulin in a Ca2+-dependent manner via this C-terminal extension, involving residues 278â€"297 in human Rad. High intracellular Gem levels, which interact with intact microtubules and microfilaments, promote profound changes in cell morphology. Ectopic Gem expression is sufficient to stimulate cell flattening and neurite extension in N1E-115 and SH-SY5Y neuroblastoma cells, suggesting a role for Gem in cytoskeletal rearrangement and/or morphological differentiation of neurons. Gem was also observed in developing trigeminal nerve ganglia in 12.5 day mouse embryos, demonstrating that Gem expression is a property of normal ganglionic development. The interaction of Gem with beta-subunits regulates Ca2+ channel expression at the cell surface. The human Gem gene maps to chromosome ,8q22.1.

Synonyms: GTP binding mitogen induced T cell protein, GTP binding protein expressed in mitogen stimulated T cells, GTP binding protein GEM, GTP binding protein overexpressed in skeletal muscle, Kinase inducible Ras like protein, KIR, MGC26294, RAS like protein KIR, GEM_HUMAN.

ID gène 2669
Domaine de recherche Signaling
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months