GLTSCR2 anticorps (AA 401-478) (HRP)

N° du produit ABIN1712325

Détail du produit anti-GLTSCR2 anticorps (HRP)

Antigène: GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))

Épitope: AA 401-478

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLTSCR2 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GLTSCR2

Antigène: GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))

Autre désignation: GLTSCR2/PICT1 (GLTSCR2 Produits)

Synonymes: anticorps GLTSCR2, anticorps pict1, anticorps pict-1, anticorps MGC115044, anticorps PICT-1, anticorps PICT1, anticorps 5330430H08Rik, anticorps 9430097C02Rik, anticorps AU041936, anticorps AW536441, anticorps R74911, anticorps NOP53 ribosome biogenesis factor, anticorps NOP53 ribosome biogenesis factor L homeolog, anticorps Nop53, anticorps NOP53, anticorps nop53, anticorps nop53.L

Sujet:

Synonyms: Glioma tumor suppressor candidate region gene 2 protein, GLTSCR2, GSCR2_HUMAN, p60, PICT1, protein interacting with carboxyl terminus 1.

Background: The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.

ID gène: 29997