GLTSCR2 anticorps (Glioma Tumor Suppressor Candidate Region Gene 2) (HRP)

Details for Product anti-GLTSCR2 Antibody No. ABIN1712325, Fournisseur: Connectez-vous pour afficher
Antigène
  • GLTSCR2
  • pict1
  • pict-1
  • MGC115044
  • PICT-1
  • PICT1
  • 5330430H08Rik
  • 9430097C02Rik
  • AU041936
  • AW536441
  • R74911
  • glioma tumor suppressor candidate region gene 2
  • Gltscr2
  • GLTSCR2
  • gltscr2
Reactivité
Humain, Souris, Rat (Rattus)
58
18
18
4
4
2
1
Hôte
Lapin
36
14
9
Clonalité
Polyclonal
Conjugué
Cet anticorp GLTSCR2 est conjugé à/à la HRP
4
4
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
33
31
13
9
3
2
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1
Isotype IgG
Purification Purified by Protein A.
Autre désignation Gltscr2/Pict1
Sujet

The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.

Synonyms: Glioma tumor suppressor candidate region gene 2 protein, GLTSCR2, GSCR2_HUMAN, p60, PICT1, protein interacting with carboxyl terminus 1.

ID gène 29997
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months