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Heparanase (HPSE) anticorps (HRP)

Détails pour le produit réf. ABIN1712343, Fournisseur: Connectez-vous pour afficher
Antigène
  • im:7144134
  • hpa
  • hpa1
  • hpr1
  • hpse1
  • hse1
  • HPSE
  • HPA
  • HPA1
  • HPR1
  • HPSE1
  • HSE1
  • Hpa
  • Hpr1
  • Hep
  • heparanase
  • HPSE
  • hpse
  • Hpse
  • LOC100101601
Alternatives
anti-Humain Heparanase anticorps pour Immunohistochemistry (Paraffin-embedded Sections)
Reactivité
Humain, Souris, Rat (Rattus)
164
88
60
3
3
3
2
2
1
Hôte
Lapin
154
39
Clonalité
Polyclonal
Conjugué
HRP
18
14
6
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
146
72
60
26
25
22
21
18
17
12
9
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human Heparanase
Isotype IgG
Purification Purified by Protein A.
Autre désignation Heparanase (HPSE Antibody Extrait)
Sujet

Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.


Synonyms: Heparanase 50 kDa subunit, heparanase, heparanase1, heparanase-1, heparanase 1, Endo glucoronidase, Endo glucoronidase, Endo-glucoronidase, HPSE_HUMAN, Heparanase1, Heparanase 1, HEP, Hpa 1, HPA, Hpa1, HPR 1, HPR1, HPSE 1, HPSE, HPSE1, HSE 1, HSE1.
Pathways Glycosaminoglycan Metabolic Process
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months