HES3 anticorps (Hairy and Enhancer of Split 3 (Drosophila)) (HRP)

Details for Product anti-HES3 Antibody No. ABIN1712344, Fournisseur: Connectez-vous pour afficher
Antigène
  • bHLHb43
  • Hes-3
  • hairy and enhancer of split 3
  • hairy and enhancer of split 3 (Drosophila)
  • LOC100351426
  • HES3
  • Hes3
Reactivité
Humain, Souris, Rat (Rattus)
15
14
14
Hôte
Lapin
15
Clonalité
Polyclonal
Conjugué
Cet anticorp HES3 est conjugé à/à la HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
13
3
1
Options
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
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Immunogène KLH conjugated synthetic peptide derived from human HES3
Isotype IgG
Purification Purified by Protein A.
Autre désignation Hes3 (HES3 Antibody Extrait)
Sujet

The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Subcellular location: Nucleus

Synonyms: bHLHb43, Class B basic helix loop helix protein 43, Hairy and enhancer of split 3, Transcription factor HES 3,

ID gène 390992
Indications d'application IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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