Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1) anticorps (HRP)

Détails pour le produit réf. ABIN1712359, Fournisseur: Connectez-vous pour afficher
Antigène
  • hm:zeh1367
  • lrrfip1
  • wu:fc06b04
  • wu:fi15c07
  • zeh1367
  • LRRFIP1
  • AU024550
  • Fliiap1
  • FLAP-1
  • FLAP1
  • FLIIAP1
  • GCF-2
  • GCF2
  • HUFI-1
  • TRIP
  • leucine rich repeat (in FLII) interacting protein 1a
  • leucine rich repeat (in FLII) interacting protein 1
  • lrrfip1a
  • LRRFIP1
  • Lrrfip1
Reactivité
Humain, Souris, Rat (Rattus)
70
19
18
4
4
4
4
4
3
1
1
Hôte
Lapin
51
19
1
Clonalité
Polyclonal
Conjugué
HRP
4
3
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
54
24
13
13
13
6
5
4
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human LRRFIP1
Isotype IgG
Purification Purified by Protein A.
Autre désignation Lrrfip1 (LRRFIP1 Antibody Extrait)
Sujet

LRRFIP1 is an 738 amino acid human protein whose rodent counterpart is known as Lrrfip1 (also designated FLAP in mouse). LRRFIP1 is also believed to control smooth muscle cell proliferation following arterial injury through PDGF-A repression. The N-terminus of LRRFIP1 shows high homology to the coiled-coil domain of FLAP, a protein which binds the leucine-rich repeat (LRR) of Flightless I, and the interaction of LRRFIP1 with the LRR of Flightless I has been confirmed. LRRFIP1 does not bind single-stranded DNA or RNA significantly and binds double-stranded DNA weakly. In contrast, LRRFIP1 binds double-stranded RNA with high affinity, and two molecules of LRRFIP1 bind the TaR stem. The RNA binding domain has been identified and encompasses a lysine-rich motif. Flightless I has a C-terminal TaR-like domain which binds Actin and therefore the association of LRRFIP1 with the LRR of Flightless I may provide a link between the Actin cytoskeleton and RNA in mammalian cells.

Synonyms: FLAP 1, FLAP1, FLIIAP 1, FLIIAP1, GC binding factor 2, GC-binding factor 2, GCF 2, GCF2, HUFI 1, HUFI1, Leucine rich repeat in FLII interacting protein 1, Leucine rich repeat flightless interacting protein 1, Leucine-rich repeat flightless-interacting protein 1, LRR FLII interacting protein 1, LRR FLII-interacting protein 1, LRRF1_HUMAN, LRRFIP 1, Lrrfip1, MGC10947, MGC119738, MGC119739, NEDD8 conjugating enzyme, TAR RNA interacting protein, TAR RNA-interacting protein, Transcription factor 9 like, TRIP.

ID gène 9208
Domaine de recherche Chromatin and Nuclear Signaling, Chromatin Binding Proteins, Transcription Factors
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months