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MAML2 anticorps (Mastermind-Like 2 (Drosophila)) (HRP)

Détail du produit anti-MAML2 anticorps No. ABIN1712360, Fournisseur: Connectez-vous pour afficher
Antigène
  • 5930431H10
  • BC032967
  • MAM-3
  • MAM2
  • MAM3
  • MLL-MAML2
  • mastermind like 2 (Drosophila)
  • mastermind-like 2 (Drosophila)
  • Maml2
  • MAML2
Reactivité
Humain, Souris, Rat (Rattus)
62
21
16
4
4
3
3
3
Hôte
Lapin
38
26
Clonalité
Polyclonal
Conjugué
Cet anticorp MAML2 est conjugé à/à la HRP
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
43
26
25
24
18
13
12
4
4
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human MAML2
Isotype IgG
Purification Purified by Protein A.
Autre désignation Maml2 (MAML2 Antibody Extrait)
Sujet

Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1). The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2). In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2). The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4). Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2). Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5). The gene which encodes Mam1 maps to human chromosome 5 (4).


Synonyms: KIAA1819, Mam 2, Mam-2, MAML2, MAML2_HUMAN, Mastermind-like protein 2.
ID gène 84441
Domaine de recherche Chromatin and Nuclear Signaling, Transcription Factors
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months