NOBOX anticorps (NOBOX Oogenesis Homeobox) (HRP)

Details for Product anti-NOBOX Antibody No. ABIN1712369, Fournisseur: Connectez-vous pour afficher
Antigène
  • OG-2
  • OG2
  • OG2X
  • POF5
  • TCAG_12042
  • Og2x
  • RGD1563929
  • NOBOX oogenesis homeobox
  • NOBOX
  • Nobox
Reactivité
Humain, Souris, Rat (Rattus)
28
16
14
1
Hôte
Lapin
26
4
Clonalité
Polyclonal
Conjugué
Cet anticorp NOBOX est conjugé à/à la HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
18
13
5
4
2
Options
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Immunogène KLH conjugated synthetic peptide derived from human NOBOX
Isotype IgG
Purification Purified by Protein A.
Autre désignation Nobox (NOBOX Antibody Extrait)
Sujet

Early ovarian folliculogenesis is characterized by the breakdown of germ cell clusters and formation of primordial follicles. The cessation of ovarian function under the age of 40 years results in premature ovarian failure (POF) and is accompanied by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. 1 % of all women are affected by POF, and mutations in a few genes, including inhibin? fsh receptor and the LH/choriogonadotropin receptor have been linked to POF. In addition, several germ cell specific genes and downstream transcription factors are thought to play and important role in human oogenesis. NOBOX (newborn ovary homeobox gene), an ooctye-specific homeobox gene, is a critical protein involved in early folliculogenesis. Missense mutations have been shown to cause nonsyndromic ovarian failure by disrupting the NOBOX proteins ability to bind to NOBOX DNA-binding element (NBE), and thereby inhibiting its regulation of Pou5f1 and GDF-9. NOBOX expression in the ovary is oocyte specific, but it shows expression in adult testis and pancreas as well.

Synonyms: Homeobox protein NOBOX, Nobox, NOBOX Oogenesis Homeobox, NOBOX_HUMAN, OG-2, OG2, Og2x, POF5, TCAG_12042.

ID gène 135935
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months