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RRM2 anticorps (Ribonucleotide Reductase M2) (HRP)

Détail du produit anti-RRM2 anticorps No. ABIN1712381, Fournisseur: Connectez-vous pour afficher
Antigène
  • RRM2
  • rrm2
  • rr2m
  • R2
  • RR2
  • RR2M
  • AA407299
  • cb111
  • chunp6884
  • r2
  • ribonucleotide reductase M2 polypeptide
  • ribonucleotide reductase M2, gene 2
  • ribonucleotide reductase M2, gene 1
  • ribonucleotide reductase M2
  • RRM2
  • rrm2.2
  • rrm2.1
  • LOC100304963
  • LOC100346325
  • LOC100359539
  • Rrm2
  • rrm2
Alternatives
anti-Humain RRM2 anticorps pour Western Blotting
Reactivité
Humain, Souris, Rat (Rattus)
79
28
28
2
2
1
1
1
Hôte
Lapin
55
21
3
Clonalité
Polyclonal
Conjugué
Cet anticorp RRM2 est conjugé à/à la HRP
4
4
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
26
20
18
16
13
9
5
2
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human RRM2
Isotype IgG
Purification Purified by Protein A.
Autre désignation Rrm2 (RRM2 Antibody Extrait)
Sujet

Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage.


Synonyms: R2, Ribonucleoside-diphosphate reductase subunit M2, Ribonucleotide reductase M2 subunit, Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit, RIR2_HUMAN, RR2, RR2M, RRM2.
ID gène 6241
Domaine de recherche Chromatin and Nuclear Signaling, DNA/RNA
Pathways Mitotic G1-G1/S Phases
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months