LCP2 anticorps (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa)) (HRP)

Details for Product anti-LCP2 Antibody No. ABIN1712386, Fournisseur: Connectez-vous pour afficher
Antigène
  • AI323664
  • BB161688
  • SLP-76
  • SLP76
  • twm
  • Slp76
  • lymphocyte cytosolic protein 2
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
  • Lcp2
  • LCP2
Alternatives
anti-Humain LCP2 anticorps pour Immunofluorescence (fixed cells)
Reactivité
Humain, Souris, Rat (Rattus)
149
93
53
32
2
2
1
1
1
Hôte
Lapin
77
58
19
Clonalité
Polyclonal
Conjugué
Cet anticorp LCP2 est conjugé à/à la HRP
4
4
4
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
128
45
45
36
15
13
6
6
3
2
1
1
1
1
1
Options
Fournisseur
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Immunogène KLH conjugated synthetic peptide derived from human SLP76
Isotype IgG
Purification Purified by Protein A.
Autre désignation Slp76 (LCP2 Antibody Extrait)
Sujet

The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.

Synonyms: 76 kDa tyrosine phosphoprotein, CG8697, LCP 2, LCP 2, LCP2, LCP2_HUMAN, Lymphocyte Cytosolic Protein 2, Lymphocyte Cytosolic Protein 2, SH2 Domain Containing Leukocyte Protein 76 KD, SH2 domain containing leukocyte protein of 76kD, SH2 domain containing leukocyte protein of 76 kDa, SH2 domain-containing leukocyte protein of 76 kDa, SLP 76, SLP 76, SLP 76 tyrosine phosphoprotein, SLP-76 tyrosine phosphoprotein, SLP76, SLP76 tyrosine phosphoprotein.

Domaine de recherche Signaling
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months