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Sorting Nexin 2 (SNX2) anticorps (HRP)

Détails pour le produit réf. ABIN1712387, Fournisseur: Connectez-vous pour afficher
Antigène
  • snx2
  • MGC64590
  • SNX2
  • LOC100219194
  • TRG-9
  • 0610030A03Rik
  • zgc:123293
  • sorting nexin 2
  • snx2
  • SNX2
  • BACOIKO006_25
  • LOC100219194
  • Snx2
Reactivité
Humain, Souris, Rat (Rattus)
59
30
25
8
6
6
4
4
4
2
2
2
1
1
1
1
Hôte
Lapin
56
2
1
Clonalité
Polyclonal
Conjugué
HRP
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
46
17
13
12
9
2
1
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human SNX2
Isotype IgG
Purification Purified by Protein A.
Autre désignation Snx2 (SNX2 Antibody Extrait)
Sujet

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901).

Subcellular location: Membrane bound


Synonyms: TRG-9, Sorting nexin-2, Transformation-related gene 9 protein, SNX2, TRG9
ID gène 6643
UniProt O60749
Domaine de recherche Signaling
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months