TLE4 anticorps (Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila)) (HRP)

Details for Product anti-TLE4 Antibody No. ABIN1712402, Fournisseur: Connectez-vous pour afficher
Antigène
  • TLE4
  • NV17443
  • BCE-1
  • BCE1
  • E(spI)
  • ESG
  • ESG4
  • GRG4
  • Esp2
  • Grg4
  • XGrg-4
  • XTCF-4
  • Xgrg4
  • Xtle4
  • esg4
  • grg4
  • gro
  • 5730411M05Rik
  • AA792082
  • Bce-1
  • Bce1
  • ESTM13
  • ESTM14
  • X83332
  • X83333
  • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
  • transducin-like enhancer of split 4 (E(sp1) homolog)
  • transducin-like enhancer of split 4, homolog of Drosophila E(spl)
  • TLE4
  • LOC100229224
  • Tle4
  • tle4
Reactivité
Humain, Souris, Rat (Rattus)
82
40
39
6
3
2
2
2
2
2
1
1
1
1
Hôte
Lapin
65
17
Clonalité
Polyclonal
Conjugué
Cet anticorp TLE4 est conjugé à/à la HRP
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
66
34
14
13
10
5
2
2
Options
Fournisseur
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Supplier Product No.
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Immunogène KLH conjugated synthetic peptide derived from human TLE4
Isotype IgG
Purification Purified by Protein A.
Autre désignation Tle4 (TLE4 Antibody Extrait)
Sujet

The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.

Synonyms: B lymphocyte gene 1, B lymphocyte gene 1, enhancer of split groucho 4, enhancer of split groucho 4, ESG4, ESG4, KIAA1261, TIM, TIM1, timeless Drosophila homolog, TLE4, transducin-like enhancer of split 4, transducin-like enhancer of split 4, TLE4_HUMAN.

ID gène 7091
Domaine de recherche Chromatin and Nuclear Signaling, Transcription Factors, Wnt
Pathways Signalisation WNT
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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