UBD anticorps (Ubiquitin D) (HRP)

Details for Product anti-UBD Antibody No. ABIN1712405, Fournisseur: Connectez-vous pour afficher
Antigène
  • FAT10
  • GABBR1
  • UBD-3
  • ubiquitin D
  • UBD
  • Ubd
  • LOC100352008
Reactivité
Humain, Souris, Rat (Rattus)
54
41
23
2
2
2
1
Hôte
Lapin
69
4
Clonalité
Polyclonal
Conjugué
Cet anticorp UBD est conjugé à/à la HRP
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
57
31
29
22
13
9
9
3
2
1
Options
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
Connectez-vous pour afficher
Immunogène KLH conjugated synthetic peptide derived from human Ubiquitin D
Isotype IgG
Purification Purified by Protein A.
Autre désignation Ubiquitin D (UBD Antibody Extrait)
Sujet

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

Subcellular location: Cytoplasm, Nucleus

Synonyms: FAT10, UBD-3, GABBR1, Ubiquitin D, Diubiquitin, Ubiquitin-like protein FAT10, UBD

ID gène 10537
UniProt O15205
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
Avez-vous cherché autre chose?