KIT anticorps (Mast/stem Cell Growth Factor Receptor) (pTyr823) (HRP)

Details for Product anti-KIT Antibody No. ABIN1712420, Fournisseur: Connectez-vous pour afficher
Antigène
  • C-Kit
  • CD117
  • PBT
  • SCFR
  • Bs
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • c-kit
  • MGF
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • kit oncogene
  • KIT
  • Kit
Alternatives
anti-Humain KIT anticorps pour Immunofluorescence (fixed cells)
Épitope
pTyr823
99
82
67
62
46
37
35
34
33
33
27
20
20
20
20
20
20
20
20
20
20
20
20
20
20
19
19
18
18
16
15
15
15
15
15
15
14
14
14
14
14
12
11
10
10
10
9
9
9
9
8
8
8
8
8
8
8
8
8
8
8
7
7
7
7
7
7
7
7
6
6
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
1380
594
162
48
42
37
29
19
15
6
6
5
5
4
3
2
1
1
Hôte
Lapin
1084
357
277
16
2
2
Clonalité
Polyclonal
Conjugué
Cet anticorp KIT est conjugé à/à la HRP
150
132
130
100
85
74
25
21
15
13
12
12
12
11
10
10
9
8
8
8
8
8
6
6
6
6
6
5
5
5
5
5
4
3
3
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
702
649
499
360
272
182
124
105
86
81
39
14
13
13
12
8
7
6
6
5
4
4
3
3
2
2
2
2
2
2
1
Options
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Immunogène KLH conjugated synthetic phosphopeptide derived from human c-Kit around the phosphorylation site of Tyr823
Isotype IgG
Purification Purified by Protein A.
Autre désignation C-Kit (KIT Antibody Extrait)
Sujet

c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

Synonyms: c-Kit phospho Y823, c-Kit phospho Tyr823, p-c-Kit Tyr 823, C Kit, c-Kit, CD 117, CD117, CD117 antigen, KIT, KIT_HUMAN, Mast/stem cell growth factor receptor, Mast/stem cell growth factor receptor Kit, p145 c-kit, PBT, Piebald trait protein, Proto oncogene c Kit, Proto oncogene tyrosine protein kinase Kit, Proto-oncogene c-Kit, SCF Receptor, SCFR, soluble KIT variant 1, Stem cell factor receptor, tyrosine protein kinase Kit, Tyrosine-protein kinase Kit, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.

ID gène 3815
Domaine de recherche Proliferation Markers
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months