ZAP70 anticorps (zeta-Chain (TCR) Associated Protein Kinase 70kDa) (pTyr292) (HRP)

Details for Product anti-ZAP70 Antibody No. ABIN1712430, Fournisseur: Connectez-vous pour afficher
Antigène
  • zap70
  • MGC80670
  • MGC88962
  • ZAP70
  • 70kDa
  • AI327364
  • Srk
  • TZK
  • ZAP-70
  • mrtle
  • mur
  • SRK
  • STCD
  • STD
  • zeta-chain (TCR) associated protein kinase 70kDa
  • tyrosine-protein kinase zap-70
  • zeta-chain (TCR) associated protein kinase
  • zeta-chain (TCR) associated protein kinase 70
  • zap70
  • ZAP70
  • Smp_149470
  • Zap70
Épitope
pTyr292
79
53
49
37
28
24
22
15
13
12
10
10
10
8
8
8
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
581
218
142
14
11
10
9
8
6
6
4
3
1
Hôte
Lapin
315
243
16
8
3
Clonalité
Polyclonal
Conjugué
Cet anticorp ZAP70 est conjugé à/à la HRP
31
24
20
18
13
9
9
7
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
319
172
169
162
158
83
52
49
23
7
5
5
4
4
4
3
3
2
2
Options
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
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Immunogène KLH conjugated synthetic phosphopeptide derived from human Zap-70 around the phosphorylation site of Tyr292
Isotype IgG
Purification Purified by Protein A.
Autre désignation Zap70 (ZAP70 Antibody Extrait)
Sujet

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Synonyms: ZAP70 phospho Y292, ZAP70 phospho Tyr292, p-Zap-70Tyr292, p-Zap-70Y292, p-ZAP70 Y292, p-ZAP70 Tyr292, ZAP-70, ZAP 70, ZAP70, zeta-associated protein 70, ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, Syk-related tyrosine kinase. SRK, STD, TZK, ZAP70_HUMAN, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein.

ID gène 7535
Domaine de recherche Signaling, Tags/Labels, Immunology, Cancer, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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