SYNGAP1 anticorps (Synaptic Ras GTPase Activating Protein 1) (pSer836) (HRP)

Details for Product anti-SYNGAP1 Antibody No. ABIN1712452, Fournisseur: Connectez-vous pour afficher
Antigène
  • SYNGAP1
  • Syngap
  • MRD5
  • RASA1
  • RASA5
  • SYNGAP
  • Gm1963
  • synaptic Ras GTPase activating protein 1
  • synaptic Ras GTPase activating protein 1 homolog (rat)
  • SYNGAP1
  • LOC100352163
  • syngap1
  • Syngap1
Alternatives
anti-Humain SYNGAP1 anticorps pour Immunofluorescence (fixed cells)
Épitope
pSer836
14
12
10
9
5
3
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
65
54
45
8
7
6
4
4
3
1
1
1
1
Hôte
Lapin
45
30
Clonalité
Polyclonal
Conjugué
Cet anticorp SYNGAP1 est conjugé à/à la HRP
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
44
30
26
8
4
4
2
2
2
1
1
Options
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Immunogène KLH conjugated synthetic hosphopeptide derived from human SynGAP around the phosphorylation site of Ser836
Isotype IgG
Purification Purified by Protein A.
Autre désignation Syngap (SYNGAP1 Antibody Extrait)
Sujet

The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway.

Synonyms: SynGAP phospho S836, SynGAP phospho Ser836, p-SynGAP Ser836, p-RASA1Ser836, Neuronal RasGAP, p135 SynGAP, Ras GTPase activating protein SynGAP, Ras GTPase-activating protein SynGAP, RASA 1, RASA 5, RASA1, RASA5, SYGP1_HUMAN, Synaptic Ras GAP 1, Synaptic Ras GTPase activating protein 1, Synaptic Ras GTPase activating protein 1 homolog, Synaptic Ras GTPase activating protein 135 kDa, synaptic Ras GTPase activating protein, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, SYNGAP 1, SYNGAP1, DKFZp761G1421, KIAA1938, MRD5, OTTHUMP00000064825.

ID gène 8831
Domaine de recherche Neurology
Pathways Regulation of long-term Neuronal Synaptic Plasticity
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months