Aprataxin anticorps (APTX) (HRP)

Details for Product anti-APTX Antibody No. ABIN1712454, Fournisseur: Connectez-vous pour afficher
Antigène
  • aptx
  • APTX
  • LOC100284636
  • APRATAXIN-like
  • T10O8.20
  • T10O8_20
  • AOA
  • AOA1
  • AXA1
  • EAOH
  • EOAHA
  • FHA-HIT
  • 2410016G21Rik
  • AA388047
  • FHA-HIT protein
  • FHA-HIT
  • aprataxin
  • adenylylsulfate sulfohydrolase
  • FHA-HIT long isoform
  • aptx
  • APTX
  • CpipJ_CPIJ001673
  • LOC100284636
  • Aptx
Reactivité
Humain, Souris, Rat (Rattus)
50
28
28
6
5
4
3
3
3
3
1
1
Hôte
Lapin
43
6
1
Clonalité
Polyclonal
Conjugué
Cet anticorp Aprataxin est conjugé à/à la HRP
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
33
18
13
13
6
5
4
1
1
1
Options
Fournisseur
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Supplier Product No.
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Immunogène KLH conjugated synthetic peptide derived from human AOA1/Aprataxin
Isotype IgG
Purification Purified by Protein A.
Autre désignation Aoa1/Aprataxin (APTX Antibody Extrait)
Sujet

Aprataxin is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. Aprataxin is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. Aprataxin contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes. These mutations either target the HIT domain or truncate the protein N-terminal to a zinc finger.

Synonyms: AOA 1, AOA, AOA, AOA1, AOA1, Aprataxin, Aprataxin, Aprataxin homolog, APTX, APTX, APTX_HUMAN, Ataxia 1 early onset with hypoalbuminemia, Ataxia 1 early onset with hypoalbuminemia, Ataxia1 early onset with hypoalbuminemia, AXA 1, AXA1, AXA1, EAOH, EAOH, EOAHA, EOAHA, FHA HIT, FHA HIT, FHA-HIT, FLJ20157, FLJ20157, Forkhead associated domain histidine triad like, Forkhead associated domain histidine triad like, Forkhead associated domain histidine triad like protein, Forkhead-associated domain histidine triad-like protein, MGC1072, MGC1072.

ID gène 54840
Pathways Réparation de l'ADN, Chromatin Binding
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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