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SMAD3 anticorps (SMAD, Mothers Against DPP Homolog 3) (pSer423) (HRP)

Détail du produit anti-SMAD3 anticorps No. ABIN1712478, Fournisseur: Connectez-vous pour afficher
Antigène
  • madh3
  • madh3a
  • smad3
  • wu:fa99e03
  • HSPC193
  • HsT17436
  • JV15-2
  • LDS1C
  • LDS3
  • MADH3
  • XSmad3
  • XenMLP
  • Xmad3
  • madh3-A
  • Madh3
  • AU022421
  • Smad 3
  • mad3
  • SMAD family member 3
  • MAD homolog 3a (Drosophila)
  • mothers against decapentaplegic homolog 3
  • SMAD3
  • smad3a
  • LOC100346303
  • smad3
  • Smad3
Alternatives
anti-Humain SMAD3 anticorps pour Western Blotting
Épitope
pSer423
49
48
45
39
24
19
19
18
17
13
11
11
11
10
8
8
8
7
7
6
5
5
5
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
472
266
247
38
29
23
23
19
18
17
13
4
3
3
3
2
2
1
1
1
1
1
1
Hôte
Lapin
417
56
15
Clonalité
Polyclonal
Conjugué
Cet anticorp SMAD3 est conjugé à/à la HRP
18
17
14
8
8
8
6
6
6
6
6
4
4
4
4
4
4
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
347
215
197
105
95
54
38
34
25
18
9
7
7
2
1
Options
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Immunogène KLH conjugated synthetic phosphopeptide derived from human Smad3 around the phosphorylation site of Ser423
Isotype IgG
Purification Purified by Protein A.
Autre désignation Smad3 (SMAD3 Antibody Extrait)
Sujet

Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8), the common partner, (Smad4) that functions via its interaction to the various Smads, and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.


Synonyms: Smad3 phospho Ser423, Smad3 phospho S423, p-Smad3 Ser423, hMAD 3, hSMAD3, HSPC193, JV15 2, JV152, MAD mothers against decapentaplegic Drosophila homolog 3, MAD3, MADH 3, MADH3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMA and MAD related protein 3, SMAD 3, SMAD, SMAD-3, SMAD3_HUMAN.
ID gène 4088
Domaine de recherche Cancer, Signaling, Transcription Factors
Pathways Cycle Cellulaire, Chromatin Binding, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Autophagy
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months