GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (Gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct.
Subcellular location: Extracellular
Synonyms: GABAA receptor, GABAA receptor subunit pi, GABRP, Gamma aminobutyric acid GABA A receptor pi, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid receptor subunit pi, Gamma-aminobutyric acid receptor subunit pi, GBRP_HUMAN, MGC126386, MGC126387.