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Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded.
Synonyms: DKFZp781F0986, Flap endonuclease GEN homolog 1, FLJ40869, GEN 1, Gen, Gen homolog 1 endonuclease Drosophila, Gen homolog 1 endonuclease, GEN_HUMAN, GEN1.