Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2) anticorps (HRP)

Détails pour le produit réf. ABIN1712546, Fournisseur: Connectez-vous pour afficher
Antigène
  • MGC53281
  • MGC132131
  • DKFZp459O1715
  • 0610011A07Rik
  • 2410043M02Rik
  • 5730520M13Rik
  • 9430094F20Rik
  • AW552058
  • GOLPH2
  • GRASP55
  • GRS2
  • p59
  • Grs2
  • MGC73072
  • zgc:73072
  • GOLPH6
  • golgi reassembly stacking protein 2, 55kDa
  • golgi reassembly stacking protein 2
  • gorasp2
  • GORASP2
  • CC1G_02936
  • Gorasp2
Reactivité
Humain, Souris, Rat (Rattus)
80
36
35
3
1
1
Hôte
Lapin
77
6
Clonalité
Polyclonal
Conjugué
HRP
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
28
18
16
13
7
7
4
4
3
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human Golgi phosphoprotein 6
Isotype IgG
Purification Purified by Protein A.
Autre désignation Gorasp2/Golgi Phosphoprotein 6/Grasp55 (GORASP2 Antibody Extrait)
Sujet

The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65 (1). GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi Cisternae (2,3). The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure (4). ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis (5).

Synonyms: Golgi phosphoprotein 6, Golgi reassembly stacking protein 2, Golgi reassembly stacking protein 2, 55 kDa, Golgi reassembly stacking protein of 55 kDa, Golgi reassembly-stacking protein 2, Golgi reassembly-stacking protein of 55 kDa, GOLPH2, GOLPH6, GORASP2, GORS2_HUMAN, GRASP55, GRS2, p59, RP23-428O15.1.

ID gène 26003
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months