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BRCA1 anticorps (Breast Cancer 1) (pSer1387) (HRP)

Détail du produit anti-BRCA1 anticorps No. ABIN1712588, Fournisseur: Connectez-vous pour afficher
Antigène
  • BRCAI
  • BRCC1
  • BROVCA1
  • IRIS
  • PNCA4
  • PPP1R53
  • PSCP
  • RNF53
  • breast cancer 1
  • breast cancer 1, early onset
  • Brca1
  • BRCA1
Alternatives
anti-Humain BRCA1 anticorps pour Immunohistochemistry (Frozen Sections)
Épitope
pSer1387
78
34
30
27
24
23
19
18
18
17
17
15
11
10
8
8
6
5
5
5
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
555
58
47
10
2
1
1
1
1
Hôte
Lapin
382
179
4
3
Clonalité
Polyclonal
Conjugué
Cet anticorp BRCA1 est conjugé à/à la HRP
23
19
18
11
11
8
8
7
6
6
6
6
6
6
6
6
6
6
5
5
5
5
5
5
5
5
3
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
334
152
118
109
98
97
95
81
78
6
5
5
5
4
2
2
1
1
Options
Fournisseur
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Immunogène KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1387
Isotype IgG
Purification Purified by Protein A.
Autre désignation Brca1 (BRCA1 Antibody Extrait)
Sujet

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].


Synonyms: BRCA1 phospho S1387, BRCA1 phospho Ser1387, p-BRCA1 S1387, p-BRCA1 Ser1387, p-BRCA1 phospho S1387, BRCA 1, BRCA1, BRCA1/BRCA2 containing complex subunit 1, BRCA1/BRCA2-containing complex, subunit 1, BRCA1_HUMAN, BRCAI, BRAC 1, BRCA 1, BRCC 1, BRCC1, Breast Cancer 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, Breast and ovarian cancer susceptibility protein 1, Breast Ovarian Cancer Susceptibility, IRIS, Papillary Serous Carcinoma Of The Peritoneum, PSCP, RING finger protein 53, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, RNF53, BAP1.
ID gène 672
Domaine de recherche Cancer, Transcription Factors, Proteolysis / Ubiquitin, DNA/RNA
Pathways Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
Indications d'application WB(1:100-1000), IHC-P(1:100-500)
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months