Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV1, HIV2 and SIV bind to DCs via DCSIGN. ICAM3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed CD299, DC-SIGNR, L-SIGN and DCSIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Subcellular location: Extracellular
Synonyms: CLEC4L, Dendritic cell-specic ICAM-3-grabbing non-integrin 1, C type lectin domain family 4 member L, CD 209, CD209, CD209 antigen, CD209 antigen-like protein A, CD209 Molecule, Cd209a, CDSIGN, CIRE, DC SIGN1, DCSIGN, Dendritic cell specic ICAM 3 grabbing nonintegrin 1, Dendritic cell specic ICAM3 grabbing nonintegrin 1, Dendritic cell-specic intracellular adhesion molecules ICAM-3 grabbing non-integrin, Dengue fever, protection against, included, Dentritic Cell Specic ICAM3 Grabbing Nonintegrin, HIV GP120 Binding Protein, MGC129965, MGC130443, SIGN-R1, SIGNR5, CD209_HUMAN.