GPBAR1 anticorps (G Protein-Coupled Bile Acid Receptor 1) (PE)

Details for Product anti-GPBAR1 Antibody No. ABIN1712675, Fournisseur: Connectez-vous pour afficher
Antigène
  • MGC84403
  • GPBAR1
  • CD344
  • EVR1
  • FEVR
  • FZD4S
  • Fz-4
  • Fz4
  • FzE4
  • GPCR
  • hFz4
  • BG37
  • GPCR19
  • GPR131
  • M-BAR
  • TGR5
  • Tgr5
  • Gpbar1
  • G protein-coupled bile acid receptor 1
  • frizzled family receptor 4
  • G protein-coupled receptor
  • gpbar1
  • GPBAR1
  • FZD4
  • Gpbar1
  • TGR5
Alternatives
anti-Humain GPBAR1 anticorps pour ELISA
Reactivité
Humain
112
21
15
4
4
3
3
2
2
1
1
1
1
1
1
Hôte
Lapin
94
19
Clonalité
Polyclonal
Conjugué
Cet anticorp GPBAR1 est conjugé à/à la PE
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
39
39
19
18
13
7
4
2
Options
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Immunogène KLH conjugated synthetic peptide derived from human GPBAR1
Isotype IgG
Purification Purified by Protein A.
Autre désignation GPBAR1 (GPBAR1 Antibody Extrait)
Sujet

The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

Subcellular location: Extracellular


Synonyms: BG 37, BG37, G protein coupled bile acid receptor 1, G protein coupled bile acid receptor BG 37, G protein coupled bile acid receptor BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPBAR1, GPCR 19, GPCR, GPCR19, GPR 131, GPR131, hBG 37, hBG37, hGPCR 19, hGPCR19, M BAR, M-BAR, Membrane bile acid receptor, Membrane type receptor for bile acids, Membrane-type receptor for bile acids, MGC40597, TGR 5, TGR5.
ID gène 151306
Pathways Signalisation WNT, Hormone Transport, Sensory Perception of Sound
Indications d'application FCM(1:20-100)
Commentaires

Exitation/Emission: 480,565nm/578nm

Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months