MHC, Class I (AA 60-105) anticorps (PE)

Détails pour le produit réf. ABIN1712680, Fournisseur: Connectez-vous pour afficher
Antigène
  • H-2K
  • H-2K(d)
  • H2-K
  • K-f
  • Y-FA
  • YFV
  • histocompatibility 2, K1, K region
  • MHC class I antigen
  • MHC class I antigen YF5
  • H2-K1
  • OVAR
  • YF5
Épitope
AA 60-105
51
38
15
Reactivité
Humain
151
149
80
32
31
30
25
24
24
22
9
7
4
4
4
4
4
4
4
3
3
3
3
Hôte
Lapin
281
35
32
Clonalité
Polyclonal
Conjugué
PE
36
35
23
14
14
12
10
10
10
10
10
10
10
10
10
7
7
7
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS)
274
124
83
55
48
41
35
26
18
16
14
5
4
3
2
2
2
2
Options
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Immunogène KLH conjugated synthetic peptide derived from human MHC class I
Isotype IgG
Purification Purified by Protein A.
Autre désignation MHC Class I
Sujet

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

Subcellular location: Extracellular


Synonyms: A 28, A 9, Aw 24, Aw 68, CLASS I HISTOCOMPATIBILITY ANTIGEN, H2 K1, H2K, HLA A, HLA-A, HLA C, HLA-C, HLA class I histocompatibility antigen A 1 alpha chain, HLA class I histocompatibility antigen A 11 alpha chain, HLA class I histocompatibility antigen A 2 alpha chain, HLA class I histocompatibility antigen A 24 alpha chain, HLA class I histocompatibility antigen A 3 alpha chain, HLA class I histocompatibility antigen A 30 alpha chain, HLA class I histocompatibility antigen A 32 alpha chain, HLA class I histocompatibility antigen A 68 alpha chain, HLAA, Major histocompatibility complex class I A, MHC class I heavy chain H2 K, 1C04_HUMAN.
UniProt G0ZMJ8
Domaine de recherche Major Histocompatibility Complex (MHC), Immunology
Indications d'application FCM(1:20-100)
Commentaires

Exitation/Emission: 480,565nm/578nm

Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months