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Maturation of cytotoxic T lymphocytes is mediated in part by a structure on the T cell surface known as the T cell antigen receptor (TCR) complex. The pre-TCR complex consists of pre-TCR i±, pre-TCR i²and CD3, which together help coordinate early thymocyte development. Pre-TCR i± chain is a type I transmembrane glycoprotein with an extracellular region similar to the constant domain of the immunoglobulin supergene family. Notch3 transgenic mice lacking pre-TCR i± inhibits tumor development. In humans, acute lymphoblastic leukemias (ALL) in remission have lower transcript levels of Notch3, HES-1 and pre-TCR i± transcripts a and b relative to proliferating ALLs. The human pre-TCR i± gene is expressed in immature T cells and maps to chromosome 6p21.3.
Subcellular location: Extracellular