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TRKA anticorps (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (PE)

Détail du produit anti-NTRK1 anticorps No. ABIN1712790, Fournisseur: Connectez-vous pour afficher
Antigène
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
Alternatives
anti-Humain TRKA anticorps pour Immunoprecipitation
Reactivité
Humain, Souris, Rat (Rattus)
406
244
197
2
2
Hôte
Lapin
369
63
4
4
2
Clonalité
Polyclonal
Conjugué
Cet anticorp TRKA est conjugé à/à la PE
16
15
15
10
9
9
8
8
8
8
8
7
7
7
7
7
6
2
2
2
2
1
1
Application
Flow Cytometry (FACS)
255
144
88
88
69
55
50
39
19
9
5
5
4
2
1
Options
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Immunogène KLH conjugated synthetic peptide derived from human TrkA
Isotype IgG
Purification Purified by Protein A.
Autre désignation TrkA (NTRK1 Antibody Extrait)
Sujet

The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.

Subcellular location: Extracellular


Synonyms: CIPA, CIPA, DKFZp781I14186, gp140trk, High affinity nerve growth factor receptor, High affinity nerve growth factor receptor precursor, High affinity nerve growth factor receptor precursor, MTC, MTC, neurotrophic tyrosine kinase receptor type 1, neurotrophic tyrosine kinase receptor type 1, Ntrk 1, Ntrk1, Ntrk1, NTRK1_HUMAN, Oncogene TRK, Oncogene TRK, p140 TrkA, p140-TrkA, TRK 1, Trk A, TRK, TRK, Trk-A, TRK1, TRK1 transforming tyrosine kinase protein, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor A, Tyrosine kinase receptor, Tyrosine Receptor Kinase A.
ID gène 4914
Domaine de recherche Cancer
Pathways Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process
Indications d'application FCM(1:20-100)
Commentaires

Exitation/Emission: 480,565nm/578nm

Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months