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EPOR anticorps

EPOR Reactivité: Humain FACS, cELISA Hôte: Souris Monoclonal VP-2E8 unconjugated
N° du produit ABIN1720915
  • Antigène Voir toutes EPOR Anticorps
    EPOR (Erythropoietin Receptor (EPOR))
    Reactivité
    • 119
    • 59
    • 49
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 107
    • 16
    • 5
    • 1
    Souris
    Clonalité
    • 115
    • 14
    Monoclonal
    Conjugué
    • 63
    • 15
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp EPOR est non-conjugé
    Application
    • 90
    • 46
    • 24
    • 23
    • 21
    • 15
    • 14
    • 14
    • 11
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Cell-ELISA (cELISA)
    Specificité
    Anti-human Epo-R
    Attributs du produit
    Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells
    Purification
    Protein G
    Immunogène
    genetic immunisation with cDNA encoding the ECD of human Epo-R
    Clone
    VP-2E8
    Isotype
    IgG1
    Top Product
    Discover our top product EPOR Anticorps primaire
  • Indications d'application
    Flow cytometry: 1.2 µg/10^6 cells
    ELISA: 1:200 - 1:400
    CELISA: 1:200 - 1:400
    For each application a titration should be performed to determine the optimal concentration.
    Commentaires

    Synonyms: Erythropoietin receptor

    Restrictions
    For Research Use only
  • Buffer
    PBS, pH 7.2
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C
    Stockage commentaire
    short term: 2 °C - 8 °C, long term: -20 °C
  • Maxwell, Melendez-Rodríguez, Matchett, Aragones, Ben-Califa, Jaekel, Hengst, Lindner, Bernardini, Brockmeier, Fandrey, Grunert, Oster, Mittelman, El-Tanani, Thiersch, Schneider Gasser, Gassmann et al.: "Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. ..." dans: British journal of haematology, Vol. 168, Issue 3, pp. 429-42, (2015) (PubMed).

    Hedley, Allan, Xenocostas: "The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 20, pp. 6373-80, (2011) (PubMed).

  • Antigène
    EPOR (Erythropoietin Receptor (EPOR))
    Autre désignation
    EPOR (EPOR Produits)
    Synonymes
    anticorps EPOR, anticorps epor, anticorps EPO-R, anticorps erythropoietin receptor, anticorps erythropoietin receptor L homeolog, anticorps EPOR, anticorps epor, anticorps Epor, anticorps epor.L
    Sujet
    Erythropoietin receptor (Epo-R) belongs to the cytokine receptor family and is a 507 amino acid type I transmembrane protein. EpoR pre-exists as dimers which changes the homodimerized state after binding of its 34 kDa ligand erythropoietin (Epo). Erythropoietin is the primary regulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. Both, Epo and Epo-R are essential for the production of red blood cells due to Epo exerts its function through the Epo receptor. The Epo-R is also expressed in many organs outside the bone marrow, suggesting that Epo is a pleiotropic anti-apoptotic factor. Signaling pathways have been shown to influence numerous cellular functions in normal and tumor cells, including proliferation, apoptosis, and drug resistance.
    UniProt
    P19235
    Pathways
    Signalistation JAK/STAT
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