Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

SYK anticorps (AA 296-484)

SYK Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 8C1A3 unconjugated
N° du produit ABIN1724704
  • Antigène Voir toutes SYK Anticorps
    SYK (Spleen tyrosine Kinase (SYK))
    Épitope
    • 29
    • 22
    • 20
    • 16
    • 10
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 296-484
    Reactivité
    • 175
    • 88
    • 53
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Humain
    Hôte
    • 158
    • 22
    • 3
    Souris
    Clonalité
    • 161
    • 21
    Monoclonal
    Conjugué
    • 106
    • 12
    • 10
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp SYK est non-conjugé
    Application
    • 148
    • 83
    • 46
    • 26
    • 23
    • 19
    • 14
    • 14
    • 13
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogène
    Purified recombinant fragment of SYK (aa296-484) expressed in E. coli.
    Clone
    8C1A3
    Isotype
    IgG1
    Top Product
    Discover our top product SYK Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Abbal, Lambelet, Bertaggia, Gerbex, Martinez, Arcaro, Schapira, Spertini: "Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions." dans: Blood, Vol. 108, Issue 10, pp. 3352-9, (2006) (PubMed).

    Kunze, Wendt, Schlott: "Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas." dans: International journal of molecular medicine, Vol. 18, Issue 4, pp. 547-57, (2006) (PubMed).

    Wossning, Herzog, Köhler, Meixlsperger, Kulathu, Mittler, Abe, Fuchs, Borkhardt, Jumaa: "Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells." dans: The Journal of experimental medicine, Vol. 203, Issue 13, pp. 2829-40, (2006) (PubMed).

  • Antigène
    SYK (Spleen tyrosine Kinase (SYK))
    Autre désignation
    SYK (SYK Produits)
    Synonymes
    anticorps p72-Syk, anticorps Sykb, anticorps p72syk, anticorps spleen associated tyrosine kinase, anticorps spleen tyrosine kinase, anticorps syk, anticorps SYK, anticorps Syk
    Sujet

    Description: SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

    Aliases: FLJ25043, FLJ37489, DKFZp313N1010

    ID gène
    6580
    HGNC
    6580
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
Vous êtes ici:
Support technique